/ Side by side
Dulaglutide vs Semaglutide
A neutral, side-by-side look at Dulaglutide and Semaglutide: what each one is, its class, half-life, storage, and the public sources behind it. Educational reference only, not medical advice, dosing, or a recommendation to use either compound.
Dulaglutide
Trulicity
Full profile →Semaglutide
Ozempic · Wegovy · Rybelsus
Full profile →| Attribute | Dulaglutide | Semaglutide |
|---|---|---|
| Category | GLP-1 / Metabolic | GLP-1 / Metabolic |
| Half-life | ~5 days, subcutaneous | ~1 week |
| Common vial | Varies | 2, 3, 5, 10 mg |
| Reference | Verified | Verified |
What is Dulaglutide?
A GLP-1 receptor agonist built as a fusion of a GLP-1 analog to an antibody Fc fragment, which slows clearance enough to support once-weekly administration. Approved for glycemic control in type 2 diabetes.
Sources
- FDA label: Trulicity (BLA 125469)
What is Semaglutide?
A GLP-1 receptor agonist, acylated for albumin binding and DPP-4 resistance, studied for glycemic control in type 2 diabetes and for weight management. Its long half-life supports once-weekly administration.
Sources
- FDA label: Ozempic, subcutaneous (NDA 209637)
- FDA label: Wegovy, subcutaneous (NDA 215256)
- FDA label: Rybelsus, oral (NDA 213051)
Educational reference only, compiled from public sources. Not medical advice, diagnosis, treatment, or a dosing recommendation, and not a recommendation to use any compound. Many compounds listed are research materials not approved for human use. Consult a qualified professional.