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Peptide half-life, side by side.

Half-life is the time it takes for a compound to fall to half its concentration in the body. It ranges from a couple of minutes for some peptides to about a week for the long-acting GLP-1 compounds. The table covers every compound in the library. Sort it by name, category, or half-life, and filter by class. Educational reference only, not medical advice, a schedule, or a dosing recommendation.

94 compounds · sorted by half-life (ascending)

Reference
ARA-290CibinetideHealing / RecoveryShort; ~2 min (IV), ~10-20 min terminal (subcutaneous)Verified
KisspeptinKisspeptin-10 · Kisspeptin-54Sexual / HormonalKisspeptin-10 ~4 min; kisspeptin-54 ~27.6 min, intravenousVerified
SemaxCognitive / LongevityMinutes in plasma (~2-5 min); intranasal or subcutaneousVerified
OxytocinPitocinSexual / Hormonal~1 to 6 min in plasmaVerified
GonadorelinGnRH · FactrelSexual / Hormonal~2-10 min (IV distribution); terminal ~10-40 minVerified
BPC-157Body Protection Compound · PL 14736Healing / RecoveryShort; ~15 min (rat, IV); no human PK publishedVerified
DSIPDelta Sleep-Inducing PeptideCognitive / LongevityShort, minutes in plasma (~7-15 min reported); IV or subcutaneousVerified
GlucagonGlucaGenGLP-1 / Metabolic~8-18 min, injectionVerified
SermorelinGeref · GHRH 1-29Growth Hormone~10-20 min (reported ~12 min), subcutaneousVerified
GHRP-2PralmorelinGrowth HormoneShort; ~30 min (approximate), subcutaneousVerified
GHRP-6Growth HormoneShort; ~20-30 min (some studies report up to ~2.5 h), subcutaneousVerified
TesamorelinEgriftaGLP-1 / Metabolic~26-38 min, subcutaneousVerified
MOTS-cMOTScGLP-1 / MetabolicNot well characterized in humans; preclinical estimates short (~45 min to a few hours)Verified
PramlintideSymlin · SymlinPenGLP-1 / Metabolic~48 min, subcutaneousVerified
HexarelinGrowth Hormone~55 min (human, subcutaneous); ~76 min IV in animal studiesVerified
Calcitonin SalmonMiacalcin · ForticalHealing / Recovery~58 min intramuscular, ~59-64 min subcutaneousVerified
AbaloparatideTymlos · BA058Healing / Recovery~1 h, subcutaneousVerified
AOD-9604AOD9604 · hGH 176-191GLP-1 / MetabolicNot well characterized in humans; reported short (minutes to ~1 h)Verified
Melanotan IIMT-2 · MT2Sexual / Hormonal~1 h, subcutaneous (limited human PK)Verified
OctreotideSandostatin · Octreotide acetateGrowth Hormone~1.7-1.9 h, injectionVerified
IpamorelinGrowth Hormone~2 h, subcutaneousVerified
SS-31ElamipretideCognitive / Longevity~2 h, subcutaneous or IVVerified
TeduglutideGattex · RevestiveHealing / Recovery~2 h in healthy subjects, ~1.3 h in short bowel syndrome, subcutaneousVerified
ExenatideByetta · BydureonGLP-1 / Metabolic~2.4 h (terminal), subcutaneousVerified
DesmopressinDDAVP · Desmopressin acetateHealing / Recovery~1.5-2.5 h, oralVerified
PT-141Bremelanotide · VyleesiSexual / Hormonal~2.7 h terminal (range 1.9-4.0 h), subcutaneousVerified
Thymosin Alpha-1Tα1 · ZadaxinHealing / Recovery~2-3 h, subcutaneousVerified
5-Amino-1MQ5A1MQCognitive / Longevity~3.8 h IV and ~6.9 h oral in rat; no published human PKVerified
NAD+Nicotinamide adenine dinucleotideCognitive / LongevityIntracellular turnover ~1-4 h (compartment-dependent); a single plasma half-life is not well definedVerified
MacimorelinMacrilen · AEZS-130Growth Hormone~4.1 h terminal, oralVerified
SetmelanotideImcivree · RM-493GLP-1 / Metabolic~11 h, subcutaneousVerified
LiraglutideSaxenda · VictozaGLP-1 / Metabolic~13 h, subcutaneousVerified
AfamelanotideScenesse · Melanotan-1Sexual / Hormonal~15 h, controlled-release subcutaneous implantVerified
MK-677Ibutamoren · NutrobalGrowth Hormone~24 h, oralVerified
Pentosan PolysulfatePPS · ElmironHealing / Recovery~20-27 h (plasma radioactivity), oralVerified
IGF-1 LR3Long R3 IGF-1Cognitive / Longevity~20-30 h reported (subcutaneous); some sources cite longerVerified
HCGHuman Chorionic Gonadotropin · NovarelSexual / HormonalBiphasic; terminal ~24-36 h, intramuscular or subcutaneousVerified
OrforglipronFOUNDAYO · LY3502970GLP-1 / Metabolic~29-49 h, oralVerified
DulaglutideTrulicityGLP-1 / Metabolic~5 days, subcutaneousVerified
TirzepatideMounjaro · ZepboundGLP-1 / Metabolic~5 days (~120 h), subcutaneousVerified
PegvisomantSomavert · B2036-PEGGrowth Hormone~60-138 h, subcutaneousVerified
RetatrutideReta · Triple-GGLP-1 / Metabolic~6 days, subcutaneousVerified
CagrilintideCagri · NN9838GLP-1 / Metabolic~7 days (~6-8 days), subcutaneousVerified
SemaglutideOzempic · WegovyGLP-1 / Metabolic~1 week (~168 h), subcutaneousVerified
SurvodutideBI 456906GLP-1 / Metabolic~6-7 days, subcutaneousVerified
CJC-1295with DAC · mod GRF 1-29Growth HormoneWith DAC ~6-8 days; without DAC (mod GRF 1-29) ~30 min, subcutaneousVerified
LanreotideSomatuline Depot · Lanreotide acetateGrowth Hormone~23-30 days, extended-release subcutaneousVerified
ACE-031ActRIIB-Fc · RamaterceptGrowth HormoneNot established in a public sourceVerified
AdipotideProhibitin-targeting peptide · FTPPGLP-1 / MetabolicNot established in a public sourceVerified
AnamorelinONO-7643 · RC-1291Growth HormoneNot established in a public sourceVerified
CagriSemaCagrilintide/SemaglutideGLP-1 / MetabolicAbout one week for both components, consistent with the weekly schedule used in trialsVerified
CerebrolysinFPF-1070Cognitive / LongevityNot established in a public source, the product being a mixture rather than a single peptideVerified
DanuglipronPF-06882961GLP-1 / MetabolicNot established in a public sourceVerified
DihexaN-hexanoic-Tyr-Ile-(6) aminohexanoic amide · PNB-0408Cognitive / LongevityNot established in a public sourceVerified
EcnoglutideXW003GLP-1 / MetabolicNot established in a public sourceVerified
EpithalonEpitalon · AEDGCognitive / LongevityNot established (no published human PK); expected short for a linear tetrapeptideEmerging
FollistatinFST · Activin-binding proteinGrowth HormoneNot established in a public sourceVerified
FOXO4-DRIFOXO4 D-retro-inverso peptideCognitive / LongevityNot established in a public sourceVerified
GDF-11Growth differentiation factor 11 · BMP-11Growth HormoneNot established in a public sourceVerified
GHK-CuCopper Peptide · Copper tripeptide-1Healing / RecoverySystemic half-life not well characterized; typically studied topicallyVerified
GHRP-1Growth hormone-releasing peptide-1Growth HormoneNot established in a public sourceVerified
GIPGlucose-dependent insulinotropic polypeptide · Gastric inhibitory polypeptideGLP-1 / MetabolicMinutes in circulation, being rapidly inactivated by DPP-4Verified
HumaninHN · Mitochondrial-derived peptideCognitive / LongevityNot established in a public sourceVerified
IGF-1 DESDES(1-3)IGF-1 · des(1-3)IGF-IGrowth HormoneNot established in a public sourceVerified
KLOWGHK-Cu + TB-500 + BPC-157 + KPVHealing / RecoveryVaries by component; see the individual entriesEmerging
KPVLysine-Proline-ValineHealing / RecoveryNot well characterized in humans (preclinical peptide)Verified
LarazotideLarazotide acetate · AT-1001Healing / RecoveryActs locally in the gut; a systemic half-life is not well definedVerified
LivagenLys-Glu-Asp-Ala · KEDA peptideCognitive / LongevityNot established in a public sourceVerified
LL-37Cathelicidin · CAP-18Healing / RecoveryShort in plasma; no human PK publishedVerified
Maridebart CafraglutideMariTide · AMG 133GLP-1 / MetabolicLong enough to support the once-monthly schedule used in trialsVerified
MazdutideIBI362 · LY3305677GLP-1 / MetabolicWeekly administration in registered trials; no human PK in a public labelVerified
MGFPEG-MGF · Mechano Growth FactorGrowth HormoneNot established in a public sourceVerified
Mod GRF 1-29CJC-1295 without DAC · Modified GRF(1-29)Growth HormoneShort, in the range of tens of minutes, and far shorter than the DAC versionVerified
N-Acetyl SelankN-Acetyl Selank Amidate · NA-SelankCognitive / LongevityNot established in a public sourceVerified
N-Acetyl SemaxN-Acetyl Semax Amidate · NA-SemaxCognitive / LongevityNot established in a public sourceVerified
NoopeptOmberacetam · GVS-111Cognitive / LongevityNot established in a public sourceVerified
PemvidutideALT-801GLP-1 / MetabolicNot established in a public sourceVerified
PetrelintideZP8396GLP-1 / MetabolicNot established in a public sourceVerified
PinealonGlu-Asp-Arg · EDR peptideCognitive / LongevityNot established in a public sourceVerified
SelankCognitive / LongevityA few minutes in plasma (rapidly degraded); intranasal or IVVerified
SLU-PP-332Pan-ERR agonistCognitive / LongevityNot established in a public sourceVerified
SpadinSortilin propeptide fragmentCognitive / LongevityNot established in a public sourceVerified
TabimorelinNN703 · NNC 26-0703Growth HormoneNot established in a public sourceVerified
TB-500Thymosin Beta-4 fragment · TB4Healing / RecoveryReported in hours; precise human PK sparse, subcutaneousVerified
TeriparatideForteo · PTH 1-34Healing / RecoveryNot stated in the cited labelVerified
TesofensineNS2330GLP-1 / MetabolicLong, multi-day reported in clinical studies; not established in a public labelVerified
ThymalinThymus polypeptide fractionHealing / RecoveryNot established in a public sourceVerified
ThymogenAlpha-glutamyl-tryptophan · Glu-TrpHealing / RecoveryNot established in a public sourceVerified
ThymopoietinTMPO · Thymopentin parent peptideHealing / RecoveryNot established in a public sourceVerified
Thymosin Beta-10TMSB10 · Tbeta10Healing / RecoveryNot established in a public sourceVerified
Thymosin Beta-4TB4 · Tbeta4Healing / RecoveryShort in plasma; no human PK publishedVerified
ThymulinZinc thymulin · Facteur thymique seriqueHealing / RecoveryNot established in a public sourceVerified
VilonLys-Glu · KE peptideCognitive / LongevityNot established in a public sourceVerified
VIPVasoactive Intestinal PeptideHealing / RecoveryVery short, on the order of minutes in plasmaVerified

Half-life is an educational pharmacology figure drawn from public sources. It describes how long a compound persists, not a schedule, a frequency, or a dosing instruction. Values marked emerging are not corroborated by an authoritative public source.

01

What half-life describes, and what it does not

Half-life is a property of the molecule and the body, measured in controlled studies. A short half-life means the compound clears quickly; a long one means it lingers. It is a useful way to understand how different compounds behave, and a poor way to invent a plan. Half-life is not a frequency, an interval, or an amount, and nothing on this page should be read as one.

02

Why the numbers vary so much

Small linear peptides are often degraded by enzymes within minutes. Engineering changes that. Attaching a fatty-acid chain or a group that binds albumin, or adding a stabilizing modification, can stretch a half-life from minutes to days. That is why two compounds in the same class can sit at opposite ends of the table. Where a figure is not established in humans, the reference column marks it as emerging rather than implying a precision that does not exist.

03

Read the full profile

Each compound name links to its full reference page: identity, mechanism class, storage and handling, and the public sources behind it. Start from the compound library to search or filter the full set.

94 compounds. Educational reference only, compiled from public sources. Not medical advice, diagnosis, treatment, or a dosing recommendation, and not a recommendation to use any compound. Many compounds listed are research materials not approved for human use. Consult a qualified professional.