/ Knowledge base

The peptide library.

A verified reference of the compounds people track: what each one is, its half-life, and the sources behind it. Search by name or brand, filter by category. Educational reference only, not medical advice, dosing, or a recommendation to use any compound.

43 compounds

Semaglutide
GLP-1 / MetabolicVerified

Semaglutide

Ozempic · Wegovy · Rybelsus

A GLP-1 receptor agonist, acylated for albumin binding and DPP-4 resistance, studied for glycemic control in type 2 diabetes and for weight management. Its long half-life supports once-weekly administration.

Half-life · ~1 week (~168 h)
Tirzepatide
GLP-1 / MetabolicVerified

Tirzepatide

Mounjaro · Zepbound

A dual GIP and GLP-1 receptor agonist with a fatty-diacid modification for albumin binding, studied for glycemic control in type 2 diabetes and for weight management. Its half-life supports once-weekly administration.

Half-life · ~5 days (~120 h)
GLP-1 / MetabolicVerified

Retatrutide

Reta · Triple-G · LY3437943

An investigational triple receptor agonist (GIP, GLP-1 and glucagon) conjugated to a fatty-diacid for albumin binding, studied in trials for obesity and metabolic disease. Its half-life supports once-weekly administration.

Half-life · ~6 days
GLP-1 / MetabolicVerified

Cagrilintide

Cagri · NN9838

A long-acting acylated amylin analog engineered to resist aggregation and bind albumin, studied in trials for appetite regulation and weight management, often alongside a GLP-1 agonist. Investigational.

Half-life · ~7 days (~6-8 days)
GLP-1 / MetabolicVerified

Liraglutide

Saxenda · Victoza

A GLP-1 receptor agonist with a fatty-acid chain enabling self-association and albumin binding, studied for glycemic control in type 2 diabetes and for weight management. Its half-life supports once-daily administration.

Half-life · ~13 h
GLP-1 / MetabolicVerified

Survodutide

BI 456906

An investigational dual glucagon and GLP-1 receptor agonist with high albumin binding, studied in trials for obesity and metabolic-associated liver disease. Its half-life supports once-weekly administration.

Half-life · ~6-7 days
GLP-1 / MetabolicVerified

AOD-9604

AOD9604 · hGH 176-191

A synthetic peptide corresponding to the C-terminal fragment of human growth hormone (residues 176-191), studied for lipolysis and fat metabolism without the glucose or IGF-1 effects of full-length growth hormone.

Half-life · Not well characterized in humans; reported short (minutes to ~1 h)
GLP-1 / MetabolicVerified

Tesamorelin

Egrifta

A stabilized growth-hormone-releasing hormone (GHRH) analog that binds pituitary GHRH receptors to stimulate endogenous growth hormone secretion. FDA-approved (Egrifta) to reduce excess visceral abdominal fat in HIV-associated lipodystrophy.

Half-life · ~26-38 min
MOTS-c
GLP-1 / MetabolicVerified

MOTS-c

MOTSc

A 16-amino-acid mitochondrial-derived peptide (encoded within mitochondrial 12S rRNA) that activates AMPK and influences metabolic and mitochondrial pathways, studied as an exercise-mimetic and for metabolic homeostasis.

Half-life · Not well characterized in humans; preclinical estimates short (~45 min to a few hours)
GLP-1 / MetabolicVerified

Tesofensine

NS2330

An orally active small-molecule triple monoamine reuptake inhibitor (serotonin, noradrenaline, and dopamine), originally developed for neurodegenerative disease and later studied in obesity and metabolic trials. It is a small molecule, not a peptide.

Half-life · ~9 days (~220 h)
BPC-157
Healing / RecoveryVerified

BPC-157

Body Protection Compound · PL 14736

A synthetic pentadecapeptide (15 amino acids) derived from a gastric protein sequence, studied in animal models for angiogenesis and soft-tissue and gastrointestinal repair. Its effects appear to outlast its brief plasma presence.

Half-life · Short; ~15 min (rat
TB-500
Healing / RecoveryVerified

TB-500

Thymosin Beta-4 fragment · TB4

A synthetic peptide based on the active actin-binding region of thymosin beta-4, a G-actin-sequestering peptide studied for cell migration, angiogenesis and tissue repair.

Half-life · Reported in hours; precise human PK sparse
Healing / RecoveryVerified

GHK-Cu

Copper Peptide · Copper tripeptide-1

A copper-binding tripeptide (glycyl-L-histidyl-L-lysine with copper) naturally present in plasma, studied for extracellular-matrix remodeling, collagen and elastin synthesis, and anti-inflammatory and antioxidant activity in skin and tissue repair.

Half-life · Systemic half-life not well characterized; typically studied topically
Healing / RecoveryVerified

KPV

Lysine-Proline-Valine

A tripeptide corresponding to the C-terminal residues of alpha-melanocyte-stimulating hormone, studied preclinically for anti-inflammatory activity via modulation of NF-kB and MAPK signaling, without the pigmentary effects of full-length alpha-MSH.

Half-life · Not well characterized in humans (preclinical peptide)
Healing / RecoveryVerified

ARA-290

Cibinetide

An 11-amino-acid non-erythropoietic peptide derived from erythropoietin that selectively activates the innate repair receptor, studied for anti-inflammatory and tissue-protective effects, including sarcoidosis-associated small-fiber neuropathy.

Half-life · Short; ~2 min (IV)
Healing / RecoveryVerified

Thymosin Alpha-1

Tα1 · Zadaxin

A 28-amino-acid immunomodulating peptide derived from prothymosin alpha that modulates Toll-like receptor signaling on dendritic cells and helps balance T-cell responses. Marketed as Zadaxin in many countries.

Half-life · ~2-3 h
Healing / RecoveryVerified

Pentosan Polysulfate

PPS · Elmiron

A semi-synthetic sulfated polysaccharide (heparin-like glycosaminoglycan), FDA-approved (Elmiron) for the pain of interstitial cystitis; thought to replenish the protective glycosaminoglycan layer of the bladder wall, with anti-inflammatory properties.

Half-life · ~20-27 h (plasma radioactivity)
Healing / RecoveryVerified

LL-37

Cathelicidin · hCAP18 · CAMP

The only human cathelicidin-derived antimicrobial peptide, a 37-residue amphipathic peptide cleaved from the hCAP18 precursor (CAMP gene) whose sequence begins with two leucines. Studied for host-defense, immunomodulatory, angiogenic, and wound-repair activity.

Half-life · Not well characterized in humans; short (endogenous
Growth HormoneVerified

Ipamorelin

A selective ghrelin/growth-hormone-secretagogue receptor (GHS-R1a) agonist pentapeptide that stimulates pituitary growth hormone release with minimal effect on cortisol or prolactin.

Half-life · ~2 h
Growth HormoneVerified

CJC-1295

with DAC · mod GRF 1-29

A synthetic growth-hormone-releasing hormone (GHRH) analog that binds pituitary GHRH receptors to stimulate growth hormone secretion. The DAC (drug affinity complex) version binds albumin for a much longer half-life than the unmodified peptide.

Half-life · With DAC ~6-8 days; without DAC (mod GRF 1-29) ~30 min
Growth HormoneVerified

Sermorelin

Geref · GHRH 1-29

A synthetic peptide corresponding to the first 29 amino acids of growth-hormone-releasing hormone that binds pituitary GHRH receptors to stimulate endogenous growth hormone secretion. Previously marketed (Geref) and used in diagnostic testing.

Half-life · ~10-20 min (reported ~12 min)
Growth HormoneVerified

MK-677

Ibutamoren · Nutrobal

An orally active, non-peptide ghrelin-receptor (GHS-R1a) agonist that produces sustained elevation of growth hormone and IGF-1. Its long half-life supports once-daily oral use.

Half-life · ~24 h
Growth HormoneVerified

GHRP-2

Pralmorelin

A synthetic ghrelin-mimetic hexapeptide (pralmorelin) that activates the growth-hormone-secretagogue receptor (GHS-R1a) to stimulate pituitary growth hormone release; used diagnostically in some countries.

Half-life · Short; ~30 min (approximate)
Growth HormoneVerified

GHRP-6

The original synthetic ghrelin-mimetic hexapeptide that activates the growth-hormone-secretagogue receptor (GHS-R1a) to stimulate pituitary growth hormone release; it also strongly stimulates appetite.

Half-life · Short; ~20-30 min (some studies report up to ~2.5 h)
Growth HormoneVerified

Hexarelin

A synthetic ghrelin-mimetic hexapeptide and potent GHS-R1a agonist, structurally related to GHRP-6, that stimulates pituitary growth hormone release; it also interacts with cardiac CD36 receptors in research settings.

Half-life · ~55 min (human
Growth HormoneVerified

MGF

PEG-MGF · Mechano Growth Factor · IGF-1Ec

Mechano Growth Factor, a splice variant of insulin-like growth factor 1 (IGF-1Ec in humans) expressed in mechanically loaded or damaged muscle. Its unique C-terminal E-domain peptide is studied for satellite-cell activation and muscle repair. PEG-MGF is a pegylated synthetic version of that peptide. Research material not approved for human use.

Half-life · Native peptide very short (minutes); pegylation (PEG-MGF) extends stability. No established human PK
Sexual / HormonalVerified

PT-141

Bremelanotide · Vyleesi

A synthetic melanocortin receptor agonist that acts on central pathways involved in sexual arousal. FDA-approved as Vyleesi and studied for hypoactive sexual desire disorder in premenopausal women.

Half-life · ~2.7 h terminal (range 1.9-4.0 h)
Sexual / HormonalVerified

Melanotan II

MT-2 · MT2

A synthetic cyclic analog of alpha-melanocyte-stimulating hormone acting as a non-selective melanocortin receptor agonist. Studied in relation to skin pigmentation and, via MC4R activation, sexual arousal. Not FDA-approved.

Half-life · ~1 h
Sexual / HormonalVerified

Kisspeptin

Kisspeptin-10 · Kisspeptin-54

Endogenous neuropeptides (KISS1 products) that agonize the KISS1R/GPR54 receptor on hypothalamic GnRH neurons, stimulating pulsatile GnRH release and downstream LH and FSH secretion. Studied in reproductive neuroendocrinology and fertility research.

Half-life · Kisspeptin-10 ~4 min; kisspeptin-54 ~27.6 min
Sexual / HormonalVerified

Gonadorelin

GnRH · Factrel

A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH) that binds pituitary GnRH receptors to stimulate release of LH and FSH. Pulsatile use stimulates them; continuous use suppresses them.

Half-life · ~2-10 min (IV distribution); terminal ~10-40 min
Sexual / HormonalVerified

HCG

Human Chorionic Gonadotropin · Novarel

A glycoprotein hormone that acts as a functional analog of luteinizing hormone, binding LH/CG receptors to stimulate gonadal steroidogenesis. FDA-approved for uses including ovulation induction and certain hypogonadotropic conditions. Dosed in international units.

Half-life · Biphasic; terminal ~24-36 h
Sexual / HormonalVerified

Melanotan I

Afamelanotide · Scenesse · MT-1 · NDP-MSH

A synthetic linear analog of alpha-melanocyte-stimulating hormone ([Nle4-D-Phe7]-alpha-MSH) that acts as a melanocortin (MC1R-preferring) agonist to stimulate eumelanin synthesis. Marketed as afamelanotide (Scenesse), an FDA-approved subcutaneous implant for photoprotection in erythropoietic protoporphyria.

Half-life · Intrinsic peptide half-life short (under ~1 h); the approved implant (Scenesse) is a bioresorbable subcutaneous depot releasing over about 2 days
Cognitive / LongevityVerified

Selank

A synthetic analog of the immunopeptide tuftsin, extended for stability, studied for anxiety-related and immunomodulatory effects. Reported mechanisms include modulation of GABAergic signaling, monoamines, and cytokines.

Half-life · A few minutes in plasma (rapidly degraded); intranasal or IV
Cognitive / LongevityVerified

Semax

A synthetic heptapeptide analog of the ACTH(4-10) fragment, studied as a neuroprotective and nootropic compound. Reported mechanisms include upregulation of neurotrophins (BDNF and NGF) and interaction with melanocortin and enkephalin systems.

Half-life · Minutes in plasma (~2-5 min); intranasal or subcutaneous
Cognitive / Longevity

Epithalon

Epitalon · AEDG

A synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly) derived from the peptide complex epithalamin, studied in aging and longevity research for reported effects on telomerase activity and melatonin/circadian regulation. Preclinical / investigational.

Half-life · Not established (no published human PK); expected short for a linear tetrapeptide
Cognitive / LongevityVerified

DSIP

Delta Sleep-Inducing Peptide

An endogenous nonapeptide first isolated for its association with delta-wave (slow-wave) sleep, studied for sleep modulation and neuroendocrine/stress effects. Its precise mechanism remains incompletely characterized.

Half-life · Short
Cognitive / LongevityVerified

NAD+

Nicotinamide adenine dinucleotide

A ubiquitous redox coenzyme central to cellular energy metabolism and a substrate for enzymes such as sirtuins and PARPs; it is a coenzyme, not a peptide. Studied in aging, metabolic, and neurological research; cellular levels reportedly decline with age.

Half-life · Intracellular turnover ~1-4 h (compartment-dependent); a single plasma half-life is not well defined
Cognitive / LongevityVerified

5-Amino-1MQ

5A1MQ

A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in preclinical metabolic research; by inhibiting NNMT it is reported to raise intracellular NAD+ and shift adipocyte metabolism toward oxidation. Not a peptide.

Half-life · ~3.8 h IV and ~6.9 h oral in rat; no published human PK
Cognitive / LongevityVerified

SS-31

Elamipretide

A mitochondria-targeted tetrapeptide that selectively binds cardiolipin in the inner mitochondrial membrane, studied for effects on mitochondrial cristae structure, ATP production, and oxidative stress. Evaluated in multiple clinical trials.

Half-life · ~2 h
Cognitive / LongevityVerified

IGF-1 LR3

Long R3 IGF-1

A synthetic long-acting analog of insulin-like growth factor 1 with reduced binding to IGF-binding proteins, used as a research reagent. It acts as an IGF-1 receptor agonist, activating anabolic PI3K/Akt and MAPK signaling. Not approved for human use.

Half-life · ~20-30 h reported (subcutaneous); some sources cite longer
Cognitive / LongevityVerified

VIP

Vasoactive Intestinal Peptide · Aviptadil

A 28-amino-acid neuropeptide of the secretin/glucagon superfamily, widely distributed in the nervous and gastrointestinal systems. It binds the VPAC1 and VPAC2 receptors and is studied for smooth-muscle relaxation, immune modulation, and circadian signaling. The synthetic form is aviptadil.

Half-life · Very short in plasma (~1-2 min); rapidly degraded by peptidases
Cognitive / LongevityVerified

Dihexa

PNB-0408 · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

A small oligopeptide derivative and angiotensin IV analog developed in academic research as a procognitive compound. In preclinical models it is reported to potentiate hepatocyte growth factor (HGF) and its c-Met receptor, associated with synaptogenesis. Research material not approved for human use.

Half-life · Not established in humans; engineered for metabolic stability relative to native angiotensin IV (no published human PK)
KLOW
Healing / Recovery

KLOW

GHK-Cu + TB-500 + BPC-157 + KPV

A combination preparation grouping the recovery peptides GHK-Cu, TB-500, BPC-157, and KPV into a single blend. Educational reference only; see each component entry for its individual profile and sources.

Half-life · Varies by component (see individual profiles)