Setmelanotide
Imcivree · RM-493
A melanocortin-4 receptor agonist approved for chronic weight management in specific genetic causes of obesity, including POMC, PCSK1 and LEPR deficiency and Bardet-Biedl syndrome. It acts on an appetite pathway distinct from the GLP-1 receptor.
Tracking and educational reference only, on values you enter or import yourself. Not medical advice or a dosing recommendation.
Regulatory status
FDA approved
The FDA has approved at least one product containing this substance for a specific medical use, which means it has been through the agency review process and carries an approved label. Approval is always for named indications in named populations, so it is not a statement that any other use has been evaluated.
A regulatory status describes paperwork, not safety. An approved compound can still be wrong for a given person, and an unapproved one is neither thereby dangerous nor thereby fine.
Half-life
~11 h, subcutaneous. Half-life is an educational pharmacology figure, drawn from public sources, and is not a schedule or dosing instruction.
Storage & handling
Supplied as a solution in a multiple-dose vial; refrigerated and protected from light per its label.
References
- FDA label: Imcivree (NDA 213793)
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Common questions
Setmelanotide, answered plainly.
01What is Setmelanotide?+
A melanocortin-4 receptor agonist approved for chronic weight management in specific genetic causes of obesity, including POMC, PCSK1 and LEPR deficiency and Bardet-Biedl syndrome. It acts on an appetite pathway distinct from the GLP-1 receptor. It is also referred to as Imcivree, RM-493. It is listed here under GLP-1 / Metabolic as educational reference, which is not a recommendation to use it.
02Is Setmelanotide FDA approved?+
FDA approved. The FDA has approved at least one product containing this substance for a specific medical use, which means it has been through the agency review process and carries an approved label. Approval is always for named indications in named populations, so it is not a statement that any other use has been evaluated.
03What is the half-life of Setmelanotide?+
~11 h, subcutaneous. A half-life is an educational pharmacology figure describing how long the body takes to clear half of a substance. It is not a schedule and does not imply one.
04How is Setmelanotide stored and handled?+
Supplied as a solution in a multiple-dose vial; refrigerated and protected from light per its label. Storage conditions come from a manufacturer's own label where one exists, and a compound with no approved label has no agency-reviewed handling instructions at all.
05What vial strengths of Setmelanotide are commonly sold?+
Commonly listed vial strengths are 10 mg. A vial strength is a market fact about how a product is packaged. It is not a dose, and it says nothing about how much of anything belongs in any person.
Related in GLP-1 / Metabolic
Educational reference only, compiled from public sources. Not medical advice, diagnosis, treatment, or a dosing recommendation, and not a recommendation to use any compound. Many compounds listed are research materials not approved for human use. Consult a qualified professional.