/ Side by side
SS-31 vs MOTS-c
A neutral, side-by-side look at SS-31 and MOTS-c: what each one is, its class, half-life, storage, and the public sources behind it. Educational reference only, not medical advice, dosing, or a recommendation to use either compound.
SS-31
Elamipretide
Full profile →MOTS-c
MOTSc
Full profile →| Attribute | SS-31 | MOTS-c |
|---|---|---|
| Category | Cognitive / Longevity | GLP-1 / Metabolic |
| Half-life | ~2 h, subcutaneous or IV | Not well characterized in humans; preclinical estimates short |
| Common vial | 10, 50 mg | 5, 10 mg |
| Reference | Verified | Verified |
What is SS-31?
A mitochondria-targeted tetrapeptide that selectively binds cardiolipin in the inner mitochondrial membrane, studied for effects on mitochondrial cristae structure, ATP production, and oxidative stress. Evaluated in multiple clinical trials.
Sources
- Elamipretide review (PMC11816484)
- MMPOWER-3 / TAZPOWER trials
What is MOTS-c?
A 16-amino-acid mitochondrial-derived peptide (encoded within mitochondrial 12S rRNA) that activates AMPK and influences metabolic and mitochondrial pathways, studied as an exercise-mimetic and for metabolic homeostasis.
Sources
- Lee et al., Cell Metab 2015
- Reynolds et al. 2021
Educational reference only, compiled from public sources. Not medical advice, diagnosis, treatment, or a dosing recommendation, and not a recommendation to use any compound. Many compounds listed are research materials not approved for human use. Consult a qualified professional.