Cognitive & Longevity Peptides
Cognitive and longevity compounds span nootropic, neuroprotective, mitochondrial, and aging-research molecules. Some are neuropeptides, others are coenzymes or small molecules grouped here for their research context. Human pharmacokinetic data is thinner in this class than elsewhere, so several entries are marked emerging rather than verified.
20 compounds
Selank
A synthetic analog of the immunopeptide tuftsin, extended for stability, studied for anxiety-related and immunomodulatory effects. Reported mechanisms include modulation of GABAergic signaling, monoamines, and cytokines.
Semax
A synthetic heptapeptide analog of the ACTH(4-10) fragment, studied as a neuroprotective and nootropic compound. Reported mechanisms include upregulation of neurotrophins (BDNF and NGF) and interaction with melanocortin and enkephalin systems.
Epithalon
Epitalon · AEDG
A synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly) derived from the peptide complex epithalamin, studied in aging and longevity research for reported effects on telomerase activity and melatonin/circadian regulation. Preclinical / investigational.
DSIP
Delta Sleep-Inducing Peptide
An endogenous nonapeptide first isolated for its association with delta-wave (slow-wave) sleep, studied for sleep modulation and neuroendocrine/stress effects. Its precise mechanism remains incompletely characterized.
NAD+
Nicotinamide adenine dinucleotide
A ubiquitous redox coenzyme central to cellular energy metabolism and a substrate for enzymes such as sirtuins and PARPs; it is a coenzyme, not a peptide. Studied in aging, metabolic, and neurological research; cellular levels reportedly decline with age.
5-Amino-1MQ
5A1MQ
A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in preclinical metabolic research; by inhibiting NNMT it is reported to raise intracellular NAD+ and shift adipocyte metabolism toward oxidation. Not a peptide.
SS-31
Elamipretide
A mitochondria-targeted tetrapeptide that selectively binds cardiolipin in the inner mitochondrial membrane, studied for effects on mitochondrial cristae structure, ATP production, and oxidative stress. Evaluated in multiple clinical trials.
IGF-1 LR3
Long R3 IGF-1
A synthetic long-acting analog of insulin-like growth factor 1 with reduced binding to IGF-binding proteins, used as a research reagent. It acts as an IGF-1 receptor agonist, activating anabolic PI3K/Akt and MAPK signaling. Not approved for human use.
Dihexa
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide · PNB-0408
A small-molecule angiotensin IV analog studied in preclinical models for hepatocyte growth factor / c-Met signalling and synapse formation. Preclinical only, with no registered human trials.
Spadin
Sortilin propeptide fragment
A peptide derived from the sortilin propeptide, studied in preclinical models as a TREK-1 potassium channel blocker in the context of mood regulation. Preclinical only.
Noopept
Omberacetam · GVS-111 · N-phenylacetyl-L-prolylglycine ethyl ester
A synthetic dipeptide studied in laboratory models for neuroprotective and cognitive endpoints. Not approved in the United States.
Humanin
HN · Mitochondrial-derived peptide
A mitochondrial-derived peptide encoded within mitochondrial DNA, studied in laboratory models for cytoprotective and apoptosis-related signalling. Research reference only.
Pinealon
Glu-Asp-Arg · EDR peptide
A short synthetic tripeptide from the Khavinson bioregulator series, studied in cell and animal models for effects on cell viability and oxidative stress. Research reference only, and the published work sits largely in a single research tradition.
Livagen
Lys-Glu-Asp-Ala · KEDA peptide
A short synthetic tetrapeptide from the Khavinson bioregulator series, studied for chromatin activation in lymphocytes and for digestive enzyme activity in animal models. Research reference only.
Vilon
Lys-Glu · KE peptide
A synthetic dipeptide from the Khavinson bioregulator series, studied in animal models for effects on proliferative and inflammatory pathways. Research reference only.
SLU-PP-332
Pan-ERR agonist
A synthetic pan-estrogen-related-receptor agonist studied in animal models for effects on fatty acid metabolism, sometimes described in press coverage as an exercise mimetic. Preclinical only, with no registered human trials.
N-Acetyl Semax
N-Acetyl Semax Amidate · NA-Semax
An acetylated analog of Semax, itself a short fragment of adrenocorticotropic hormone with the hormonal activity removed. Studied largely in Russian literature for effects on the central nervous system. Not approved outside its country of origin.
N-Acetyl Selank
N-Acetyl Selank Amidate · NA-Selank
An acetylated analog of Selank, which is itself a synthetic analog of the immune peptide tuftsin. Studied largely in Russian literature as an anxiolytic candidate. Not approved outside its country of origin.
Cerebrolysin
FPF-1070
A preparation of low molecular weight peptides and amino acids derived from porcine brain tissue, studied in stroke and dementia trials and the subject of a Cochrane review. Marketed in some countries; not FDA approved.
FOXO4-DRI
FOXO4 D-retro-inverso peptide
A synthetic D-retro-inverso peptide built on the FOXO4 sequence, designed to interfere with the interaction between FOXO4 and p53 inside senescent cells. Studied in animal models in the senescence literature. Not approved for human use.
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Educational reference only, compiled from public sources. Not medical advice, diagnosis, treatment, or a dosing recommendation, and not a recommendation to use any compound. Many compounds listed are research materials not approved for human use. Consult a qualified professional.